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DORN1


DORN1 refers to a purinergic receptor found in green plants.

In contrast to animal purinergic receptors (which are G protein-coupled receptors), DORN1 is a lectin receptor kinase (LecRK).

DORN1 receptors may play a role in mediating wound-induced inflammatory responses in green plants, with ATP acting as a damage-associated molecular pattern molecule. In response to cell lysis, ATP is discharged and binds onto the extracellular lectin domain of the DORN1 receptor. The intracellular DORN1 kinase domain is subsequently activated, resulting in several cellular responses such as mitogen-activated protein kinase activation, increased cytosolic calcium concentration, and the induction of gene expression.

In green plants such as Arabidopsis thaliana, several varieties lacking the DORN1 receptors are unable to phosphorylate mitogen-activated protein kinases after ATP stimulation.


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