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DNase I

DNASE1
Dnase1.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DNASE1, DNL1, DRNI, deoxyribonuclease I
External IDs OMIM: 125505 MGI: 103157 HomoloGene: 3826 GeneCards: DNASE1
RNA expression pattern
PBB GE DNASE1 210165 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005223

NM_010061

RefSeq (protein)

NP_005214

NP_034191.3

Location (UCSC) Chr 16: 3.61 – 3.68 Mb Chr 16: 4.04 – 4.04 Mb
PubMed search

4AWN

NM_005223

NM_010061

NP_005214

NP_034191.3

Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1. DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.


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Wikipedia

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