DNMT3A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4U7T, 4QBR, 4U7P, 4QBS, 3A1B, 3LLR, 4QBQ, 3SVM, 3A1A, 2QRV

Identifiers

Aliases

DNMT3A, DNMT3A2, M.HsaIIIA, TBRS, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA methyltransferase 3 alpha

External IDs

MGI: 1261827 HomoloGene: 7294 GeneCards: DNMT3A

Genetically Related Diseases

Crohn's disease

Gene ontology
Molecular function	• methyltransferase activity • transferase activity • DNA binding • DNA-methyltransferase activity • chromatin binding • metal ion binding • protein binding • identical protein binding • DNA (cytosine-5-)-methyltransferase activity
Cellular component	• cytoplasm • euchromatin • nuclear matrix • nucleoplasm • nuclear heterochromatin • heterochromatin • XY body • chromosome, centromeric region • nucleus
Biological process	• response to ionizing radiation • regulation of gene expression by genetic imprinting • C-5 methylation of cytosine • response to estradiol • positive regulation of cell death • cellular response to ethanol • aging • negative regulation of transcription from RNA polymerase II promoter • DNA methylation involved in gamete generation • response to vitamin A • DNA methylation • methylation • negative regulation of gene expression, epigenetic • response to nutrient levels • response to lead ion • methylation-dependent chromatin silencing • spermatogenesis • neuron differentiation • mitotic cell cycle • cellular response to amino acid stimulus • regulation of gene expression • DNA methylation involved in embryo development • response to ethanol • response to toxic substance • cellular response to hypoxia • response to drug • hepatocyte apoptotic process • response to cocaine • DNA methylation on cytosine • covalent chromatin modification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1788


13435

Ensembl


ENSG00000119772


ENSMUSG00000020661

UniProt


Q9Y6K1


O88508

RefSeq (mRNA)

NM_022552 NM_153759 NM_175629 NM_175630 NM_001320892
NM_001320893


NM_001271753 NM_007872 NM_153743

RefSeq (protein)

NP_001307821 NP_001307822 NP_072046 NP_715640 NP_783328
NP_783329

NP_001258682.1 NP_031898.1 NP_714965.1 NP_001258682 NP_031898
NP_714965

Location (UCSC)

Chr 2: 25.23 – 25.34 Mb

Chr 12: 3.81 – 3.91 Mb

PubMed search

4U7T, 4QBR, 4U7P, 4QBS, 3A1B, 3LLR, 4QBQ, 3SVM, 3A1A, 2QRV

NM_001271753
NM_007872
NM_153743

NP_783329

NP_714965

...
Wikipedia