DLX4

Identifiers

DLX4, BP1, DLX7, DLX8, DLX9, Dlx-4, OFC15, distal-less homeobox 4

External IDs

MGI: 94904 HomoloGene: 7292 GeneCards: DLX4

Gene ontology
Molecular function	• DNA binding • protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• multicellular organism development • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1748


13394

Ensembl


ENSG00000108813


ENSMUSG00000020871

UniProt


Q92988


P70436

RefSeq (mRNA)


NM_001934 NM_138281


NM_007867

RefSeq (protein)


NP_001925 NP_612138


NP_031893

Location (UCSC)

Chr 17: 49.97 – 49.97 Mb

Chr 11: 95.14 – 95.15 Mb

PubMed search

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.

Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.

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Wikipedia