DLX3

DLX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XRS
Identifiers
Aliases	DLX3, AI4, TDO, AV237891, Dlx-3, distal-less homeobox 3
External IDs	MGI: 94903 HomoloGene: 74544 GeneCards: DLX3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • sequence-specific DNA binding • chromatin binding Cellular component • nucleus Biological process • multicellular organism development • regulation of transcription, DNA-templated • placenta development • blood vessel development • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • odontoblast differentiation • odontogenesis of dentin-containing tooth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1747	13393
Ensembl	ENSG00000064195	ENSMUSG00000001510
UniProt	O60479	Q64205
RefSeq (mRNA)	NM_005220	NM_010055
RefSeq (protein)	NP_005211	NP_034185
Location (UCSC)	Chr 17: 49.99 – 50 Mb	Chr 11: 95.12 – 95.13 Mb
PubMed search

4XRS

1747

13393

ENSG00000064195

ENSMUSG00000001510

O60479

Q64205

NM_005220

NM_010055

NP_005211

NP_034185

Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.

Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Specifically, colocalization of phosphorylated Smad1 / 5 / 8 complex and Dlx3 regulate role for BMP signaling to Dlx3 during hair morphogenesis in animal models.

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17.

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