DLL4

DLL4
Identifiers
Aliases	DLL4, hdelta2, AOS6, delta like canonical Notch ligand 4
External IDs	MGI: 1859388 HomoloGene: 10411 GeneCards: DLL4
Gene ontology Molecular function • calcium ion binding • Notch binding • protein binding Cellular component • integral component of membrane • membrane • plasma membrane Biological process • Notch signaling pathway • dorsal aorta morphogenesis • cell differentiation • negative regulation of blood vessel endothelial cell migration • response to stimulus • negative regulation of transcription from RNA polymerase II promoter • blood vessel lumenization • cellular response to fibroblast growth factor stimulus • blood circulation • negative regulation of gene expression • nervous system development • ventricular trabecula myocardium morphogenesis • negative regulation of endothelial cell migration • regulation of neural retina development • positive regulation of neural precursor cell proliferation • negative regulation of cell migration involved in sprouting angiogenesis • cell communication • multicellular organism development • blood vessel remodeling • T cell differentiation • positive regulation of gene expression • ventral spinal cord interneuron fate commitment • angiogenesis • pericardium morphogenesis • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis • branching involved in blood vessel morphogenesis • Notch receptor processing • cellular response to vascular endothelial growth factor stimulus • cardiac atrium morphogenesis • cardiac ventricle morphogenesis • regulation of neurogenesis • signal transduction • visual perception • negative regulation of cell proliferation • negative regulation of Notch signaling pathway • positive regulation of Notch signaling pathway • Notch signaling involved in heart development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54567	54485
Ensembl	ENSG00000128917	ENSMUSG00000027314
UniProt	Q9NR61	Q9JI71
RefSeq (mRNA)	NM_019074	NM_019454
RefSeq (protein)	NP_061947	NP_062327.2 NP_062327
Location (UCSC)	Chr 15: 40.93 – 40.94 Mb	Chr 2: 119.33 – 119.34 Mb
PubMed search

54567

54485

ENSG00000128917

ENSMUSG00000027314

Q9NR61

Q9JI71

NM_019074

NM_019454

NP_061947

NP_062327.2
NP_062327

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

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