DLC1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DKY, 2GYT, 2KAP, 2LOZ, 3KUQ, 5FZT

Identifiers

DLC1, ARHGAP7, HP, STARD12, p122-RhoGAP, DLC1 Rho GTPase activating protein

External IDs

Genetically Related Diseases

Gene ontology
Molecular function	• SH2 domain binding • protein binding • lipid binding • GTPase activator activity
Cellular component	• cytosol • membrane • ruffle membrane • cell junction • cortical actin cytoskeleton • caveola • nucleus • cytoplasm • focal adhesion
Biological process	• positive regulation of execution phase of apoptosis • regulation of actin cytoskeleton organization • positive regulation of protein dephosphorylation • negative regulation of Rho protein signal transduction • heart morphogenesis • focal adhesion assembly • neural tube closure • regulation of cell shape • hindbrain morphogenesis • forebrain development • negative regulation of stress fiber assembly • regulation of Rho protein signal transduction • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of small GTPase mediated signal transduction • negative regulation of focal adhesion assembly • actin cytoskeleton organization • signal transduction • negative regulation of cell proliferation • apoptotic process • negative regulation of cell migration • positive regulation of GTPase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10395


50768


ENSG00000164741


ENSMUSG00000031523


Q96QB1


Q9R0Z9

RefSeq (mRNA)

NM_001164271 NM_001316668 NM_006094 NM_024767 NM_182643
NM_001348081 NM_001348082 NM_001348083 NM_001348084


NM_001194940 NM_001194941 NM_015802 NM_178735

RefSeq (protein)

NP_001157743 NP_001303597 NP_006085 NP_079043 NP_872584
NP_001335010 NP_001335011 NP_001335012 NP_001335013


NP_001181870.1 NP_056617.2 NP_001181869 NP_001181870 NP_056617

Location (UCSC)

PubMed search