DJ-1

PARK7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z
Identifiers
Aliases	PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
External IDs	MGI: 2135637 HomoloGene: 38295 GeneCards: PARK7
Gene ontology Molecular function • receptor binding • repressing transcription factor binding • cytokine binding • core promoter binding • cupric ion binding • transcription factor binding • L-dopa decarboxylase activator activity • peptidase activity • kinase binding • tyrosine 3-monooxygenase activator activity • enzyme binding • mRNA binding • protein homodimerization activity • scaffold protein binding • small protein activating enzyme binding • single-stranded DNA binding • ubiquitin-like protein conjugating enzyme binding • protein binding • peroxiredoxin activity • double-stranded DNA binding • copper ion binding • mercury ion binding • transcription coactivator activity • oxidoreductase activity, acting on peroxide as acceptor • androgen receptor binding • superoxide dismutase copper chaperone activity • RNA binding • identical protein binding • ubiquitin-specific protease binding • hydrolase activity • cuprous ion binding • cadherin binding • protein deglycase activity Cellular component • cytoplasm • cytosol • membrane • mitochondrial intermembrane space • mitochondrion • neuron projection • nucleus • mitochondrial respiratory chain complex I • endoplasmic reticulum • membrane raft • chromatin • extracellular exosome • plasma membrane • mitochondrial matrix • cell body • PML body • presynapse • perinuclear region of cytoplasm • cell-cell adherens junction • axon Biological process • negative regulation of neuron apoptotic process • positive regulation of transcription regulatory region DNA binding • negative regulation of protein sumoylation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of protein binding • synaptic transmission, dopaminergic • positive regulation of interleukin-8 production • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • Ras protein signal transduction • cellular response to glyoxal • negative regulation of protein acetylation • positive regulation of reactive oxygen species biosynthetic process • positive regulation of oxidative phosphorylation uncoupler activity • positive regulation of protein kinase B signaling • negative regulation of protein catabolic process • adult locomotory behavior • regulation of neuron apoptotic process • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of cell death • glycolate biosynthetic process • positive regulation of protein homodimerization activity • negative regulation of gene expression • single fertilization • positive regulation of peptidyl-serine phosphorylation • positive regulation of mitochondrial electron transport, NADH to ubiquinone • negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway • negative regulation of oxidative stress-induced cell death • inflammatory response • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • regulation of supramolecular fiber organization • negative regulation of neuron death • negative regulation of protein phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of protein kinase activity • negative regulation of oxidative stress-induced neuron death • membrane depolarization • protein stabilization • mitochondrion organization • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of death-inducing signaling complex assembly • negative regulation of apoptotic process • proteolysis • negative regulation of protein K48-linked deubiquitination • enzyme active site formation via L-cysteine sulfinic acid • dopamine uptake involved in synaptic transmission • positive regulation of tyrosine 3-monooxygenase activity • positive regulation of L-dopa decarboxylase activity • negative regulation of hydrogen peroxide-induced neuron death • regulation of inflammatory response • regulation of androgen receptor signaling pathway • negative regulation of hydrogen peroxide-induced cell death • positive regulation of mitophagy • response to hydrogen peroxide • detoxification of copper ion • positive regulation of superoxide dismutase activity • positive regulation of dopamine biosynthetic process • positive regulation of protein localization to nucleus • positive regulation of L-dopa biosynthetic process • activation of protein kinase B activity • membrane hyperpolarization • detoxification of mercury ion • negative regulation of TRAIL-activated apoptotic signaling pathway • cellular oxidant detoxification • negative regulation of ubiquitin-specific protease activity • regulation of TRAIL receptor biosynthetic process • autophagy • cellular response to reactive oxygen species • regulation of mitochondrial membrane potential • negative regulation of protein ubiquitination • hydrogen peroxide metabolic process • positive regulation of gene expression • negative regulation of protein export from nucleus • negative regulation of ubiquitin-protein transferase activity • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • cellular response to oxidative stress • positive regulation of androgen receptor activity • positive regulation of pyrroline-5-carboxylate reductase activity • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • methylglyoxal metabolic process • lactate biosynthetic process • peptidyl-cysteine deglycation • peptidyl-arginine deglycation • peptidyl-lysine deglycation • protein deglycation, glyoxal removal • protein deglycation, methylglyoxal removal • glutathione deglycation • glyoxal metabolic process • negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway • positive regulation of acute inflammatory response to antigenic stimulus • protein deglycosylation • positive regulation of NAD(P)H oxidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11315	57320
Ensembl	ENSG00000116288	ENSMUSG00000028964
UniProt	Q99497	Q99LX0
RefSeq (mRNA)	NM_001123377 NM_007262	NM_020569
RefSeq (protein)	NP_001116849 NP_009193	NP_065594.2 NP_065594
Location (UCSC)	Chr 1: 7.95 – 7.99 Mb	Chr 4: 150.9 – 150.91 Mb
PubMed search

1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A, 3BWE, 3CY6, 3CYF, 3CZ9, 3CZA, 3EZG, 3F71, 3SF8, 4BTE, 4MNT, 4MTC, 4N0M, 4N12, 4OGF, 4OQ4, 4P2G, 4P34, 4P35, 4P36, 4ZGG, 4RKW, 4RKY, 4S0Z

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