DISC1

DISC1

Identifiers

DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1

External IDs

OMIM: 605210 MGI: 2447658 HomoloGene: 10257 GeneCards: DISC1

Gene ontology
Molecular function	• protein complex binding • protein binding • kinesin binding • protein complex scaffold
Cellular component	• cytoplasm • ciliary basal body • cell body • centrosome • postsynaptic membrane • membrane • kinesin complex • synaptic vesicle • postsynaptic density • plasma membrane • synapse • ciliary base • microtubule organizing center • axon • cell junction • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • dynein complex • microtubule • cytoskeleton • nucleus • cytosol • central region of growth cone
Biological process	• positive regulation of neuroblast proliferation • protein localization • regulation of neuron projection development • positive regulation of cell-matrix adhesion • neuron migration • mitochondrial calcium ion homeostasis • response to electrical stimulus • Wnt signaling pathway • nervous system development • multicellular organism development • positive regulation of Wnt signaling pathway • cellular protein localization • TOR signaling • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of neuron projection development • regulation of synapse maturation • canonical Wnt signaling pathway • protein localization to centrosome • positive regulation of axon extension • cerebral cortex radially oriented cell migration • cell proliferation in forebrain • pyramidal neuron migration • microtubule cytoskeleton organization • regulation of dendritic spine development • regulation of synaptic transmission, glutamatergic • cilium morphogenesis • non-motile cilium assembly
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE DISC1 207759 s at fs.png

PBB GE DISC1 206090 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


27185


244667


ENSG00000162946


ENSMUSG00000043051


Q9NRI5


Q811T9

RefSeq (mRNA)

NM_018662 NM_001012957 NM_001012958 NM_001012959 NM_001039383
NM_001164537 NM_001164538 NM_001164539 NM_001164540 NM_001164541 NM_001164542 NM_001164544 NM_001164545 NM_001164546 NM_001164547 NM_001164548 NM_001164549 NM_001164550 NM_001164551 NM_001164552 NM_001164553 NM_001164554 NM_001164555 NM_001164556


NM_170596 NM_174853 NM_174854

RefSeq (protein)

NP_001012975 NP_001012976 NP_001012977 NP_001158009 NP_001158010
NP_001158011 NP_001158012 NP_001158013 NP_001158014 NP_001158016 NP_001158017 NP_001158018 NP_001158019 NP_001158020 NP_001158021 NP_001158022 NP_001158023 NP_001158024 NP_001158025 NP_001158026 NP_001158027 NP_001158028 NP_061132 NP_001158024.1 NP_001158010.1


NP_777278.2 NP_777279.2 NP_777278 NP_777279

Location (UCSC)

Chr 1: 231.63 – 232.04 Mb

Chr 8: 125.05 – 125.26 Mb

PubMed search

ENSG00000162946

ENSMUSG00000043051

NM_001164537
NM_001164538
NM_001164539
NM_001164540
NM_001164541
NM_001164542
NM_001164544
NM_001164545
NM_001164546
NM_001164547
NM_001164548
NM_001164549
NM_001164550
NM_001164551
NM_001164552
NM_001164553
NM_001164554
NM_001164555
NM_001164556

...
Wikipedia

...