DAZ3
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| Aliases | DAZ3, pDP1679, deleted in azoospermia 3 | ||||||||||||||||
| External IDs | HomoloGene: 133282 GeneCards: DAZ3 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr Y: 24.76 – 24.81 Mb | n/a | |||||||||||||||
| PubMed search | n/a | ||||||||||||||||
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Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene.
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat.
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Wikipedia