D. Mark Hegsted

David Mark Hegsted (March 25, 1914 – June 16, 2009) was an American nutritionist who studied the connections between food consumption and heart disease. His work included studies that showed that consumption of saturated fats led to increases in harmful cholesterol, leading to the development of dietary guidelines intended to help Americans achieve better health through improved food choices. After his death, researchers uncovered his connections to research funded by the sugar industry in which Hegsted played down connections between sugar consumption and heart disease, focusing on saturated fats as the culprit.

Hegsted was born on March 25, 1914 in Rexburg, Idaho. He graduated in 1936 from the University of Idaho and was awarded a Doctor of Philosophy in biochemistry in 1940 from the University of Wisconsin. He came to the Department of Nutrition at the Harvard School of Public Health in 1942, after spending a year at Abbott Laboratories as a research chemist. He was named as a professor of nutrition in 1962 and remained at Harvard until 1978.

Research performed by Hegsted in the early 1960s studied the relationships between changes in diet and serum levels of cholesterol. The "Hegsted equation" he developed showed that cholesterol and saturated fats from sources such as eggs and meat in the diet raised harmful cholesterol levels, monounsaturated fats had little effect and polyunsaturated fats from sources such as nuts and seeds lowered levels. Results from these studies were published in 1965 in the American Journal of Clinical Nutrition, to what was described by The New York Times as "great acclaim". In combination with research performed independently by Ancel Keys, these results led to recommendations advocating decreased dietary consumption of saturated fats. In 1967, Hegsted and two other Harvard scientists took, without attribution, $6,500 (nearly $50,000 in 2016 equivalent dollars) from the Sugar Association to produce a review of industry-selected research. The resulting paper in the New England Journal of Medicine "minimized the link between sugar and heart health and cast aspersions on the role of saturated fat [as primarily causing heart problems]". The paper helped to shape nutrition guidance for decades away from even considering the dangers to the heart of sugar and its role in obesity in the human diet.

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