Cysteinyl leukotriene receptor 1

CYSLTR1
Identifiers
Aliases	CYSLTR1, CYSLT1, CYSLT1R, CYSLTR, HMTMF81, cysteinyl leukotriene receptor 1
External IDs	MGI: 1926218 HomoloGene: 4837 GeneCards: CYSLTR1
Targeted by Drug
montelukast, pranlukast, zafirlukast
Gene ontology Molecular function • G-protein coupled peptide receptor activity • G-protein coupled receptor activity • leukotriene receptor activity • signal transducer activity • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • defense response • positive regulation of cytosolic calcium ion concentration • respiratory gaseous exchange • chemotaxis • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • leukotriene signaling pathway • circulatory system process • neuropeptide signaling pathway • calcium ion transport • signal transduction • inflammatory response to antigenic stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10800	58861
Ensembl	ENSG00000173198	ENSMUSG00000052821
UniProt	Q9Y271	Q99JA4
RefSeq (mRNA)	NM_006639 NM_001282186 NM_001282187 NM_001282188	NM_001281859 NM_001281862 NM_021476
RefSeq (protein)	NP_001269115 NP_001269116 NP_001269117 NP_006630	NP_001268788.1 NP_001268791.1 NP_067451.2 NP_001268788 NP_001268791 NP_067451
Location (UCSC)	Chr X: 78.27 – 78.33 Mb	Chr X: 106.57 – 106.6 Mb
PubMed search

10800

58861

ENSG00000173198

ENSMUSG00000052821

Q9Y271

Q99JA4

NM_006639
NM_001282186
NM_001282187
NM_001282188

NM_001281859
NM_001281862
NM_021476

NP_001269115
NP_001269116
NP_001269117
NP_006630

NP_067451

Cysteinyl leukotriene receptor 1, also termed CYSLTR1, is a receptor for cysteinyl leukotrienes (LT) (see leukotrienes#Cysteinyl leukotrienes). CYSLTR1, by binding these cysteinyl LTs (CysLTs; viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans as well as models of the reactions in other animals.

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