Cyrus Chothia
| Cyrus Chothia | |
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Cyrus Chothia (right), pictured with Alex Bateman at the ISMB conference in 2015.
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| Born | Cyrus Homi Chothia February 19, 1942 |
| Institutions | |
| Alma mater | |
| Thesis | The crystal structures of some molecules active at cholinergic nerve receptors[4] (1973) |
| Doctoral advisor | Peter J. Pauling |
| Other academic advisors |
Michael Levitt Frederic M. Richards |
| Doctoral students |
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| Other notable students | Arthur Lesk (postdoc) |
| Notable awards |
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Website www2 |
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Cyrus Homi Chothia (b. 19 Feb. 1942)FRS is an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) and emeritus fellow of Wolfson College, Cambridge.
Chothia was educated at Alleyn's School, then went to study at Durham University graduating with a Bachelor of Science degree in 1965. Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a PhD from University College London under the supervision of Peter Pauling, the son of Linus Pauling.
After his Ph.D. Chothia worked in the Laboratory of Molecular Biology (LMB) for three years. He then worked with Michael Levitt at the Weizmann Institute of Science followed by two years with Joel Janin at the Institut Pasteur in Paris.
In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk he showed that proteins adapt to mutations by changes in structure.
In 1992 he proposed that most proteins are built of domains that come from a small number of families. He collaborated with Alexey Murzin, Steven Brenner and Tim Hubbard to create the Structural Classification of Proteins (SCOP) database, a periodic table for all known protein structures. With Julian Gough he created the SUPERFAMILY database which uses Hidden Markov models to identify protein sequences that are related to those of known structures.
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