Cyclizine

Cyclizine
Clinical data


Trade names	Marezine, Valoid, Nausicalm, others
AHFS/Drugs.com	Consumer Drug Information
Pregnancy category	AU: A US: B (No risk in non-human studies)
Routes of administration	by mouth, IM, IV
ATC code	R06AE03 (WHO)
Legal status
Legal status	AU: S3 (Pharmacist only) UK: POM (Prescription only) US: OTC OTC (Netherlands)
Pharmacokinetic data
Metabolism	N-demethylated to inactive norcyclizine
Biological half-life	20 hours
Identifiers
IUPAC name 1-benzhydryl-4-methyl-piperazine
CAS Number	82-92-8^Y
PubChem CID	6726
IUPHAR/BPS	7151
DrugBank	DB01176^Y
ChemSpider	6470^Y
UNII	QRW9FCR9P2
KEGG	D03621^Y
ChEBI	CHEBI:3994^Y
ChEMBL	CHEMBL648^Y
ECHA InfoCard	100.001.314
Chemical and physical data
Formula	C₁₈H₂₂N₂
Molar mass	266.381 g/mol
3D model (Jmol)	Interactive image
SMILES CN(CC1)CCN1C(C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3^Y Key:UVKZSORBKUEBAZ-UHFFFAOYSA-N^Y

Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. It may also be used for nausea after general anaesthesia or that which developed from opioid use. It is taken by mouth, in the rectum, or injected into a vein.

Common side effects include sleepiness, dry mouth, constipation, and trouble with vision. More serious side effects include low blood pressure and urinary retention. It is not generally recommended in young children or those with glaucoma. Cyclizine appears to be safe during pregnancy but has not been well studied. It is in the anticholinergic and antihistamine family of medications.

Cyclizine was discovered in 1947. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. In the United States it is available over the counter. In the United Kingdom 100 tablets costs about 11.26 pounds. It is occasionally used for the "high" it can create.

Nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operatively following administration of general anaesthesia and opioids. It is sometimes given in hyperemesis gravidarum, although the manufacturer advises that it be avoided in pregnancy. Off-licence use often occurs with specialists in hospitals to treat inpatients who have become severely dehydrated in pregnancy. An off-label use is as an opioid/opiate potentiator.

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Wikipedia