Cyclin D3

CCND3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3G33
Identifiers
Aliases	CCND3
External IDs	MGI: 88315 HomoloGene: 20419 GeneCards: CCND3
Gene ontology Molecular function • cyclin-dependent protein serine/threonine kinase activity • protein binding • protein kinase binding Cellular component • nucleoplasm • plasma membrane • cyclin-dependent protein kinase holoenzyme complex • membrane • nucleus • focal adhesion • cytoplasm • cytosol Biological process • T cell proliferation • cell cycle • positive regulation of protein phosphorylation • signal transduction • positive regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cell cycle • cell division • negative regulation of transcription from RNA polymerase II promoter • regulation of cell proliferation • regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	896	12445
Ensembl	ENSG00000112576	ENSMUSG00000034165
UniProt	P30281	P30282
RefSeq (mRNA)	NM_001136017 NM_001136125 NM_001136126 NM_001287427 NM_001287434 NM_001760	NM_001081635 NM_001081636 NM_007632
RefSeq (protein)	NP_001129489 NP_001129597 NP_001129598 NP_001274356 NP_001274363 NP_001751	NP_001075104.1 NP_001075105.1 NP_031658.1
Location (UCSC)	Chr 6: 41.93 – 42.05 Mb	Chr 17: 47.51 – 47.6 Mb
PubMed search

3G33

896

12445

ENSG00000112576

ENSMUSG00000034165

P30281

P30282

NM_001760

NM_001081635
NM_001081636
NM_007632

NP_001751

NP_001075104.1
NP_001075105.1
NP_031658.1

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.

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