Cyclin B1

CCNB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2B9R, 2JGZ, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CCNB1, CCNB, cyclin B1
External IDs	MGI: 3648694 HomoloGene: 68982 GeneCards: CCNB1
Gene ontology Molecular function • histone kinase activity • kinase activity • patched binding • protein binding • protein kinase binding • cyclin-dependent protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase activator activity Cellular component • cytoplasm • centrosome • spindle pole • membrane • condensed nuclear chromosome outer kinetochore • nucleoplasm • microtubule organizing center • cytoskeleton • nucleus • cytosol • mitochondrial matrix • cyclin B1-CDK1 complex Biological process • negative regulation of protein phosphorylation • response to DDT • regulation of mitotic cell cycle spindle assembly checkpoint • histone H3-S10 phosphorylation involved in chromosome condensation • positive regulation of mRNA 3'-end processing • protein complex assembly • tissue regeneration • positive regulation of fibroblast proliferation • cellular response to iron(III) ion • cellular response to organic cyclic compound • response to mechanical stimulus • positive regulation of mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • in utero embryonic development • negative regulation of gene expression • regulation of cell cycle • cell division • positive regulation of attachment of spindle microtubules to kinetochore • protein phosphorylation • mitotic nuclear envelope disassembly • positive regulation of histone phosphorylation • cellular response to fatty acid • positive regulation of cardiac muscle cell proliferation • positive regulation of cell cycle • G2/M transition of mitotic cell cycle • oocyte maturation • spermatogenesis • cell cycle • mitotic metaphase plate congression • anaphase-promoting complex-dependent catabolic process • regulation of chromosome condensation • digestive tract development • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • ventricular cardiac muscle cell development • cellular response to hypoxia • response to toxic substance • response to drug • mitotic spindle organization • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • mitotic cell cycle • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle • positive regulation of mitochondrial ATP synthesis coupled electron transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	891	434175
Ensembl	ENSG00000134057	n/a
UniProt	P14635	n/a
RefSeq (mRNA)	NM_031966	n/a
RefSeq (protein)	NP_114172	n/a
Location (UCSC)	Chr 5: 69.17 – 69.18 Mb	n/a
PubMed search

2B9R, 2JGZ, 4Y72, 5HQ0, 4YC3

891

434175

ENSG00000134057

n/a

P14635

n/a

NM_031966

n/a

NP_114172

n/a

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.

Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase of the cell cycle. The different transcripts result from the use of alternate transcription initiation sites.

Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and positive feedback loops ensure that once the cyclin B1-Cdk1 complex is activated, it is not deactivated. Cyclin B1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly.

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Wikipedia