Cyclin-dependent kinase 1

CDK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YC6, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cyclin dependent kinase 1
External IDs	OMIM: 116940 MGI: 88351 HomoloGene: 68203 GeneCards: CDK1
Targeted by Drug
dinaciclib
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • cyclin-dependent protein serine/threonine kinase activity • histone kinase activity • kinase activity • Hsp70 protein binding • protein binding • RNA polymerase II carboxy-terminal domain kinase activity • ATP binding • protein serine/threonine kinase activity • chromatin binding • cyclin binding • cyclin-dependent protein kinase activity Cellular component • centrosome • membrane • spindle • nucleoplasm • microtubule organizing center • midbody • spindle microtubule • mitochondrion • mitotic spindle • extracellular exosome • cytoskeleton • nucleus • nuclear chromosome, telomeric region • cyclin-dependent protein kinase holoenzyme complex • cytoplasm • cytosol Biological process • positive regulation of protein localization to nucleus • centrosome cycle • regulation of embryonic development • response to cadmium ion • mitotic nuclear division • positive regulation of protein import into nucleus, translocation • epithelial cell differentiation • response to organic cyclic compound • phosphorylation • protein complex assembly • response to copper ion • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • G1/S transition of mitotic cell cycle • positive regulation of mitotic cell cycle • negative regulation of apoptotic process • pronuclear fusion • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of transcription involved in G1/S transition of mitotic cell cycle • response to activity • regulation of Schwann cell differentiation • cell division • positive regulation of DNA replication • cell aging • DNA replication • protein phosphorylation • histone phosphorylation • mitotic nuclear envelope disassembly • positive regulation of gene expression • positive regulation of cardiac muscle cell proliferation • activation of MAPK activity • chromosome condensation • G2/M transition of mitotic cell cycle • response to axon injury • peptidyl-serine phosphorylation • animal organ regeneration • response to organonitrogen compound • response to amine • DNA repair • cell cycle • anaphase-promoting complex-dependent catabolic process • microtubule cytoskeleton organization • response to ethanol • mitotic G2 DNA damage checkpoint • Golgi disassembly • peptidyl-threonine phosphorylation • cell migration • ventricular cardiac muscle cell development • response to toxic substance • response to hydrogen peroxide • response to drug • cellular response to hydrogen peroxide • protein localization to kinetochore • apoptotic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • cell proliferation • proteasome-mediated ubiquitin-dependent protein catabolic process • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • mitotic cell cycle • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of mitotic cell cycle • regulation of gene expression • mitotic cell cycle phase transition • regulation of meiotic cell cycle • ciliary basal body docking Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	983	12534
Ensembl	ENSG00000170312	ENSMUSG00000019942
UniProt	P06493	P11440
RefSeq (mRNA)	NM_001130829 NM_001170406 NM_001170407 NM_001786 NM_033379 NM_001320918	NM_007659
RefSeq (protein)	NP_001163877 NP_001163878 NP_001307847 NP_001777 NP_203698	NP_031685.2 NP_031685
Location (UCSC)	Chr 10: 60.78 – 60.79 Mb	Chr 10: 69.34 – 69.35 Mb
PubMed search

4YC6, 4Y72, 5HQ0, 4YC3

983

12534

ENSG00000170312

ENSMUSG00000019942

P06493

P11440

NM_001320918

NM_007659

NP_001163877
NP_001163878
NP_001307847
NP_001777
NP_203698

NP_031685.2
NP_031685

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. In humans, Cdk1 is encoded by the CDC2 gene. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.

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Wikipedia