Coordinates: 55°38′02″N 4°46′48″W / 55.634°N 4.780°W Cunninghame (Scottish Gaelic: Coineagan) is a former comital district of Scotland and also a district of the Strathclyde Region from 1975–1996.
The origin of the name is uncertain: a map of the 6th century shows the original spelling as Canowan. However a possible derivation (along with the surname Cunningham) is from cuinneag which means 'milk pail' in Gaelic and the Saxon ham which means 'village'.
The historic district of Cunninghame was bordered by the districts of Renfrew and Clydesdale to the north and east respectively, by the district of Kyle to the south over the River Irvine and by the Firth of Clyde to the west.
Cunninghame became one of the three districts or bailieries of Ayrshire, the shire or sheriffdom of Ayr. Cunninghame was in the north, along the River Irvine; Kyle was in the centre, along the River Ayr; and Carrick was in the south, along the River Doon. By the eighteenth century Ayrshire had become one of the counties of Scotland, with the three baileries being described as "districts" or "divisions" of the county, although they had no formal administrative existence.