Cryopyrin

NLRP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QF2, 2NAQ
Identifiers
Aliases	NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3
External IDs	OMIM: 606416 MGI: 2653833 HomoloGene: 3600 GeneCards: NLRP3
Gene ontology Molecular function • sequence-specific DNA binding • nucleotide binding • transcription factor binding • protein binding • peptidoglycan binding • ATP binding • identical protein binding Cellular component • cytoplasm • NLRP3 inflammasome complex • cytosol • extracellular region • endoplasmic reticulum • inflammasome complex • nucleus Biological process • defense response • detection of biotic stimulus • NLRP3 inflammasome complex assembly • regulation of transcription, DNA-templated • negative regulation of acute inflammatory response • positive regulation of interleukin-5 production • interleukin-1 secretion • interleukin-18 production • immune system process • positive regulation of interleukin-4 production • GO:0006350 transcription, DNA-templated • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of interleukin-13 production • positive regulation of T-helper 17 cell differentiation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • protein oligomerization • positive regulation of interleukin-1 beta secretion • positive regulation of T-helper 2 cell differentiation • regulation of inflammatory response • interleukin-1 beta production • positive regulation of type 2 immune response • inflammatory response • negative regulation of NF-kappaB transcription factor activity • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of NF-kappaB import into nucleus • negative regulation of inflammatory response • cellular response to lipopolysaccharide • negative regulation of interleukin-1 beta secretion • positive regulation of T-helper 2 cell cytokine production • signal transduction • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • innate immune response • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	114548	216799
Ensembl	ENSG00000162711	ENSMUSG00000032691
UniProt	Q96P20	Q8R4B8
RefSeq (mRNA)	NM_001079821 NM_001127461 NM_001127462 NM_001243133 NM_004895 NM_183395	NM_145827
RefSeq (protein)	NP_001073289 NP_001120933 NP_001120934 NP_001230062 NP_004886 NP_899632	NP_665826
Location (UCSC)	Chr 1: 247.42 – 247.45 Mb	Chr 11: 59.54 – 59.57 Mb
PubMed search

3QF2, 2NAQ

114548

216799

ENSG00000162711

ENSMUSG00000032691

Q96P20

Q8R4B8

NM_183395

NM_145827

NP_899632

NP_665826

NACHT, LRR and PYD domains-containing protein 3 (NALP3) also known by cryopyrin is a protein that in humans is encoded by the NLRP3 gene located on the long arm of chromosome 1.

NALP3 is expressed predominantly in macrophages and as a component of the inflammasome, detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.

...
Wikipedia