Cox1
| Cytochrome c oxidase subunit I | |||||||||
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Structure of the 13-subunit oxidized cytochrome c oxidase.
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| Identifiers | |||||||||
| Symbol | COX1 or COI | ||||||||
| Pfam | PF00115 | ||||||||
| InterPro | IPR000883 | ||||||||
| PROSITE | PDOC00074 | ||||||||
| SCOP | 1occ | ||||||||
| SUPERFAMILY | 1occ | ||||||||
| TCDB | 3.D.4 | ||||||||
| OPM superfamily | 4 | ||||||||
| OPM protein | 1v55 | ||||||||
| CDD | cd01663 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
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Cytochrome c oxidase I (COX1) also known as mitochondrially encoded cytochrome c oxidase I (MT-CO1) is a protein that in humans is encoded by the MT-CO1 gene. In other eukaryotes, the gene is called COX1, CO1, or COI. Cytochrome c oxidase I is the main subunit of the complex.
Cytochrome c oxidase subunit I (CO1 or MT-CO1) is one of three (mtDNA) encoded subunits (MT-CO1, MT-CO2, MT-CO3) of respiratory complex IV. Complex IV is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation.
(EC 1.9.3.1) is a key enzyme in aerobic metabolism. Proton pumping heme-copper oxidases represent the terminal, energy-transfer enzymes of respiratory chains in prokaryotes and eukaryotes. The CuB-heme a3 (or heme o) binuclear centre, associated with the largest subunit I of cytochrome c and ubiquinol oxidases (EC 1.10.3.10), is directly involved in the coupling between dioxygen reduction and proton pumping. Some terminal oxidases generate a transmembrane proton gradient across the plasma membrane (prokaryotes) or the mitochondrial inner membrane (eukaryotes).
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