Cosimo Rosselli (1439–1507) was an Italian painter of the Quattrocento, active mainly in his birthplace of Florence, but also Lucca earlier in his career, and from 1480 in the Sistine Chapel in Rome, where he painted some of the large fresco panels on the side walls. Despite being roughly the same age (slightly older in each case) as Sandro Botticelli, Pietro Perugino and Domenico Ghirlandaio, the other leading Florentine painters, all regarded as greater talents, Rosselli was still able to win several large commissions, which is a testament to the high level of activity in the city.
He painted almost entirely religious subjects, with a few portraits. He did other large frescos with his workship, from which Fra Bartolomeo and Piero di Cosimo, who married Roselli's daughter, were his most famous pupils. These include a chapel in Sant'Ambrogio, Florence and one of the large spaces in the cloister of Santissima Annunziata, Florence.
Cosimo was born in Florence. In 1460, at the age of fourteen, he became a pupil of Neri di Bicci, working as an assistant to his cousin Bernardo di Stefano Rosselli. A first youthful work of Cosimo mentioned by Giorgio Vasari is the Assumption of the Virgin altarpiece in the third chapel on the left of the nave in Sant'Ambrogio in Florence. In the same church, on the wall of one of the chapels, is a fresco by Cosimo which Vasari praises highly, especially for a portrait of the young scholar Pico of Mirandola. The scene, a procession bearing a miracle-working chalice, is painted with vigor and less mannerism than most of this artist's work. A picture painted by Rosselli for the church of the Annunziata, with figures of SS. Barbara, Matthew and the Baptist, is in the Academy of Florence.