Corticotropin releasing factor

CRH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EHU, 3EHT, 1GOE
Identifiers
Aliases	CRH, CRF, CRH1, corticotropin releasing hormone
External IDs	OMIM: 122560 MGI: 88496 HomoloGene: 599 GeneCards: CRH
Gene ontology Molecular function • hormone activity • corticotropin-releasing hormone receptor 1 binding • corticotropin-releasing hormone receptor 2 binding • protein binding • neuropeptide hormone activity • receptor binding • corticotropin-releasing hormone activity Cellular component • cytoplasm • perikaryon • varicosity • extracellular region • neuronal cell body • extracellular space Biological process • response to cocaine • response to immobilization stress • positive regulation of cAMP biosynthetic process • positive regulation of cortisol secretion • steroid metabolic process • positive regulation of protein phosphorylation • negative regulation of luteinizing hormone secretion • positive regulation of cell death • associative learning • ion homeostasis • lung development • negative regulation of blood pressure • diterpenoid metabolic process • response to corticosterone • female pregnancy • negative regulation of norepinephrine secretion • adrenal gland development • positive regulation of corticotropin secretion • synaptic transmission, dopaminergic • negative regulation of cell death • negative regulation of gene expression • cellular response to dexamethasone stimulus • positive regulation of corticosterone secretion • response to estrogen • locomotory exploration behavior • regulation of NMDA receptor activity • regulation of serotonin secretion • positive regulation of calcium ion import • glucocorticoid biosynthetic process • positive regulation of gene expression • positive regulation of digestive system process • parturition • response to pain • positive regulation of circadian sleep/wake cycle, wakefulness • positive regulation of cell proliferation • hypothalamus development • learning or memory • hormone-mediated apoptotic signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • response to ethanol • inflammatory response • negative regulation of circadian sleep/wake cycle, REM sleep • response to ether • positive regulation of behavioral fear response • response to drug • signal transduction • cellular response to cocaine • long-term synaptic potentiation • chemical synaptic transmission • negative regulation of epinephrine secretion • negative regulation of glucagon secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1392	12918
Ensembl	ENSG00000147571	ENSMUSG00000049796
UniProt	P06850	Q8CIT0
RefSeq (mRNA)	NM_000756	NM_205769
RefSeq (protein)	NP_000747	NP_991338
Location (UCSC)	Chr 8: 66.18 – 66.18 Mb	Chr 3: 19.69 – 19.7 Mb
PubMed search

3EHU, 3EHT, 1GOE

1392

12918

ENSG00000147571

ENSMUSG00000049796

P06850

Q8CIT0

NM_000756

NM_205769

NP_000747

NP_991338

Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response. It is a releasing hormone that belongs to corticotropin-releasing factor family. In humans, it is encoded by the CRH gene.

Its main function is the stimulation of the pituitary synthesis of ACTH, as part of the HPA Axis.

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Wikipedia