Coramine

Nikethamide

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R07AB02 (WHO)
Pharmacokinetic data
Biological half-life	0.5 h
Identifiers
IUPAC name N,N-Diethyl-3-pyridinecarboxamide
Synonyms	Nicotinic acid diethylamide
CAS Number	59-26-7 Y
PubChem (CID)	5497
ChemSpider	5296 Y
UNII	368IVD6M32 Y
KEGG	D07408 Y
ECHA InfoCard	100.000.380
Chemical and physical data
Formula	C10H14N2O
Molar mass	178.231
3D model (Jmol)	Interactive image
SMILES O=C(N(CC)CC)c1cccnc1
InChI InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 Y Key:NCYVXEGFNDZQCU-UHFFFAOYSA-N Y

Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now considered to be of no value for such purposes, and may be dangerous.

In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.

Coramine was used by suspected serial killer John Bodkin Adams when treating patient Gertrude Hullett, whom he was suspected of murdering. However, the toxicity of nikethamide is quite low (LD₅₀ rabbits 650 mg/kg oral, LD₅₀ rats 240 mg/kg subcutaneous).

Theodor Morell, Adolf Hitler's personal physician, would inject the German ruler with Coramine when Hitler was unduly sedated with barbiturates. In addition, Morell would use Coramine as part of an all-purpose "tonic" for Hitler.

It is available as a short-acting over-the-counter drug in several South American and European countries, combined with glucose in form of lozenges. It is especially useful for mountain climbers to increase endurance at high altitudes. Contraindications include hypertension, cardiovascular pathologies and epilepsy.

In some sports, nikethamide is listed by the World Anti-Doping Agency as a banned substance. Croatian tennis player Marin Čilić was suspended from competition for nine months after he tested positive for nikethamide in April 2013. This ban was later reduced to four months after Cilic appealed and claimed he had unintentionally ingested it in a glucose tablet bought at a pharmacy. Polish kart driver Igor Walilko was given a two-year ban, later reduced to eighteen months, from competition in 2010 due to testing positive for nikethamide after a win in Germany in July, 2010.