Constantine I (Georgian: კონსტანტინე I მუხრანბატონი, Konstantine I Mukhranbatoni) (fl. 1622 – 1667) was a Georgian prince and the head of the Mukhrani branch of the royal Bagrationi dynasty of Kartli. He was Prince (Mukhranbatoni) of Mukhrani and ex officio commander of the Banner of Shida Kartli from 1658 to 1667.
Constantine I was the second son of Teimuraz I, by his wife Ana, daughter of Nugzar, Duke of Aragvi of the House of Sidamoni. He was born between 1618 and 1622. In 1658, Constantine succeeded as Prince of Mukhrani his elder brother Vakhtang, who became King of Kartli on the death of his adopted father, Rostom, the last in the main male line of the Bagrationi of Kartli. On this occasion, Vakhtang, as a vassal of Safavid Persia, converted to Islam, but Constantine remained Christian. He is buried at the Cathedral of Mtskheta.
Constantine married Darejan, daughter of Prince Ghuana Abashidze (died 1667) and had the following children: