Complement receptor 1

CR1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9
Identifiers
Aliases	CR1, C3BR, C4BR, CD35, KN, complement component 3b/4b receptor 1 (Knops blood group)
External IDs	OMIM: 120620 HomoloGene: 55474 GeneCards: CR1
Genetically Related Diseases
Alzheimer's disease
Gene ontology Molecular function • virus receptor activity • complement component C3b receptor activity • complement component C4b receptor activity • complement component C3b binding • complement component C4b binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • extracellular exosome • secretory granule membrane • ficolin-1-rich granule membrane Biological process • negative regulation of complement activation, classical pathway • immune system process • positive regulation of serine-type endopeptidase activity • negative regulation of complement activation, alternative pathway • complement activation, classical pathway • viral entry into host cell • viral process • negative regulation of serine-type endopeptidase activity • regulation of complement activation • complement receptor mediated signaling pathway • innate immune response • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1378	n/a
Ensembl	ENSG00000203710	n/a
UniProt	P17927	n/a
RefSeq (mRNA)	NM_000573 NM_000651	n/a
RefSeq (protein)	NP_000564 NP_000642	n/a
Location (UCSC)	Chr 1: 207.5 – 207.64 Mb	n/a
PubMed search		n/a

1GKG, 1GKN, 1PPQ, 2Q7Z, 2MCY, 2MCZ, 5FO9

1378

n/a

ENSG00000203710

n/a

P17927

n/a

NM_000573
NM_000651

n/a

NP_000564
NP_000642

n/a

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene.

This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

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Wikipedia