Complement component 6

C6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3T5O, 4A5W, 4E0S
Identifiers
Aliases	C6
External IDs	MGI: 88233 HomoloGene: 47 GeneCards: C6
Gene ontology Molecular function • protein binding Cellular component • extracellular region • extracellular exosome • membrane attack complex Biological process • positive regulation of activation of membrane attack complex • immune system process • complement activation • in utero embryonic development • cytolysis • regulation of complement activation • immune response • positive regulation of angiogenesis • complement activation, classical pathway • positive regulation of complement activation • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	729	12274
Ensembl	ENSG00000039537	ENSMUSG00000022181
UniProt	P13671	n/a
RefSeq (mRNA)	NM_000065 NM_001115131	NM_016704
RefSeq (protein)	NP_000056 NP_001108603	n/a
Location (UCSC)	Chr 5: 41.14 – 41.26 Mb	Chr 15: 4.73 – 4.82 Mb
PubMed search

3T5O, 4A5W, 4E0S

729

12274

ENSG00000039537

ENSMUSG00000022181

P13671

n/a

NM_000065
NM_001115131

NM_016704

NP_000056
NP_001108603

n/a

Complement component 6 is a protein that in humans is encoded by the C6 gene.

Complement component 6 is a protein involved in the complement system. It is part of the membrane attack complex which can insert into the cell membrane and cause cell to lyse.

People with C6 deficiency are prone to bacterial infection.

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Wikipedia