The Combahee River (/kəmˈbiː/ kəm-BEE) is a short blackwater river in the southern Lowcountry region of South Carolina formed at the confluence of the Salkehatchie and Little Salkehatchie rivers near the Islandton community of Colleton County, South Carolina. Part of its lower drainage basin combines with the Ashepoo River and the Edisto River to form the ACE Basin The Combahee empties into Saint Helena Sound near Beaufort, which in turn empties into the Atlantic Ocean.
The river is named for its first inhabitants, the Combahee tribe of Native Americans. Europeans settled the area as early as the 1680s, and so the Combahee and others of the Cusabo group are also known as Settlement Indians. Land was set aside for the Yemassee people along several rivers, including the Combahee. The Yemassee War of 1715-1717 saw skirmishes in the area.
On 27 August 1782, one of the last fights in the Revolutionary War took place along the Combahee River. The British made an attempt at foraging, which the Americans, headed by General Gist and Colonel John Laurens opposed. Laurens, the son of Henry Laurens, a former president of the Continental Congress, died in the action.