Colony stimulating factor 1 receptor

CSF1R

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM

Identifiers

Aliases

CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor

External IDs

MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R

EC number

2.7.10.1

Gene ontology
Molecular function	• nucleotide binding • protein tyrosine kinase activity • protein kinase activity • transferase activity • transmembrane receptor protein tyrosine kinase activity • kinase activity • protein homodimerization activity • ATP binding • protein phosphatase binding • macrophage colony-stimulating factor receptor activity • cytokine binding
Cellular component	• integral component of membrane • integral component of plasma membrane • membrane • cell surface • CSF1-CSF1R complex • nucleoplasm • plasma membrane • intracellular membrane-bounded organelle
Biological process	• negative regulation of cell proliferation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of protein serine/threonine kinase activity • mammary gland duct morphogenesis • positive regulation of cell motility • macrophage colony-stimulating factor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of chemokine secretion • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • signal transduction • axon guidance • multicellular organism development • monocyte differentiation • macrophage differentiation • ruffle organization • positive regulation of cell migration • cellular response to cytokine stimulus • protein autophosphorylation • hemopoiesis • peptidyl-tyrosine phosphorylation • olfactory bulb development • regulation of bone resorption • phosphatidylinositol metabolic process • protein phosphorylation • positive regulation of protein tyrosine kinase activity • cell-cell junction maintenance • osteoclast differentiation • innate immune response • regulation of actin cytoskeleton reorganization • immune system process • inflammatory response • positive regulation of protein phosphorylation • forebrain neuron differentiation • phosphorylation • cytokine-mediated signaling pathway • cellular response to macrophage colony-stimulating factor stimulus • positive regulation of cell proliferation • regulation of cell shape • cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1436


12978

Ensembl


ENSG00000182578


ENSMUSG00000024621

UniProt


P07333


P09581

RefSeq (mRNA)


NM_001288705 NM_005211 NM_001349736


NM_001037859 NM_007779

RefSeq (protein)


NP_001275634 NP_005202 NP_001336665


NP_001032948

Location (UCSC)

Chr 5: 150.05 – 150.11 Mb

Chr 18: 61.11 – 61.13 Mb

PubMed search

2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM

NM_001288705
NM_005211
NM_001349736

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