Coagulation factor II receptor

F2R

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 3BEF, 3HKI, 3HKJ, 3LU9, 3VW7

Identifiers

Aliases

F2R, CHTR, PAR-1, PAR1, TR, Coagulation factor II receptor, coagulation factor II thrombin receptor

External IDs

MGI: 101802 HomoloGene: 1510 GeneCards: F2R

Gene ontology
Molecular function	• G-protein coupled receptor activity • signal transducer activity • thrombin-activated receptor activity • G-protein beta-subunit binding • protein binding • G-protein alpha-subunit binding • receptor binding
Cellular component	• integral component of membrane • platelet dense tubular network • late endosome • Golgi apparatus • postsynaptic membrane • membrane • neuromuscular junction • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • early endosome • caveola
Biological process	• negative regulation of neuron apoptotic process • positive regulation of collagen biosynthetic process • hemostasis • G-protein coupled receptor signaling pathway • establishment of synaptic specificity at neuromuscular junction • release of sequestered calcium ion into cytosol • platelet dense granule organization • positive regulation of interleukin-6 secretion • regulation of sensory perception of pain • thrombin-activated receptor signaling pathway • activation of MAPKK activity • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • anatomical structure morphogenesis • blood coagulation • positive regulation of release of sequestered calcium ion into cytosol • STAT protein import into nucleus • tyrosine phosphorylation of STAT protein • platelet activation • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to lipopolysaccharide • positive regulation of transcription, DNA-templated • protein kinase C-activating G-protein coupled receptor signaling pathway • positive regulation of blood coagulation • response to wounding • positive regulation of vasoconstriction • positive regulation of cell proliferation • connective tissue replacement involved in inflammatory response wound healing • positive regulation of ERK1 and ERK2 cascade • regulation of interleukin-1 beta production • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of interleukin-8 secretion • homeostasis of number of cells within a tissue • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of blood coagulation • inflammatory response • negative regulation of glomerular filtration • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of smooth muscle contraction • positive regulation of JAK-STAT cascade • positive regulation of MAPK cascade • negative regulation of cell proliferation • negative regulation of renin secretion into blood stream • signal transduction • positive regulation of calcium ion transport • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2149


14062

Ensembl


ENSG00000181104


ENSMUSG00000048376

UniProt


P25116


P30558

RefSeq (mRNA)


NM_001992 NM_001311313


NM_010169

RefSeq (protein)


NP_001298242 NP_001983


NP_034299.2 NP_034299

Location (UCSC)

Chr 5: 76.72 – 76.74 Mb

Chr 13: 95.6 – 95.62 Mb

PubMed search

1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 3BEF, 3HKI, 3HKJ, 3LU9, 3VW7

NM_001992
NM_001311313

NM_010169

NP_001298242
NP_001983

NP_034299.2
NP_034299

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