Cleopatra of Macedon (Greek: Κλεοπάτρα; c. 355/354 BC – 308 BC), or Cleopatra of Epirus, was an Epirote-Macedonian princess and later queen regent of Epirus. The daughter of Philip II of Macedon and Olympias of Epirus, she was the only full sibling of Alexander the Great. Her other siblings include half sisters Thessalonike and Cynane, and half brother Philip III of Macedon.
She grew up in the care of her mother in Pella, like a normal princess. In 338 BC, Cleopatra stayed in Pella with her father while her mother Olympias fled to exile in Epirus with her Molossian brother Alexander I of Epirus (Cleopatra's uncle), and Cleopatra's brother Alexander fled to Illyria. Soon Philip felt he had to ally himself to Alexander I by offering his daughter's hand in marriage. A large wedding between Cleopatra and her uncle Alexander I of Epirus was held in 336 BC. It was at the celebration of her nuptials, which took place on a magnificent scale at Aegae in Macedon, that Philip II was murdered.
Immediately after her father's murder, the two newlyweds went from Macedon back to Epirus. Soon after, the couple welcomed two children, Neoptolemus II of Epirus and Cadmeia. Leaving Pella did not mean leaving her family behind, as it is believed that Alexander and Cleopatra kept in close contact while he was on his conquest to the east. In 332 BC Alexander had sent booty home for both his mother and sister, as well as his close friends.
In 334 BC, Cleopatra's husband crossed the Adriatic Sea to the Italian peninsula to campaign against several Italic tribes, the Lucanians and Bruttii, on behalf of the Greek colony Taras, leaving her as regent of Epirus. She was involved as recipient and sender of official shipments of grain during a widespread shortage around 334 BC. According to an inscription from Cyrene, Libya she was the recipient of 50,000 'medimni' of grain, and shipped the surplus to Corinth. Alexander I conquered Heraclea, took Sipontum, and captured both Consentia and Terin, but was eventually killed in battle in 331 BC, leaving the young heir, Neoptolemus too young for the throne.