Ciliary neurotrophic factor

CNTF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CNT
Identifiers
Aliases	CNTF, Hciliary neurotrophic factor
External IDs	OMIM: 118945 MGI: 88439 HomoloGene: 8288 GeneCards: CNTF
Gene ontology Molecular function • interleukin-6 receptor binding • protein binding • ciliary neurotrophic factor receptor binding • growth factor activity • cytokine activity Cellular component • cytoplasm • CRLF-CLCF1 complex • extracellular region • axon • extracellular space Biological process • negative regulation of neuron apoptotic process • cell differentiation • muscle organ morphogenesis • neuron development • regulation of retinal cell programmed cell death • nervous system development • ciliary neurotrophic factor-mediated signaling pathway • multicellular organism development • growth • negative regulation of photoreceptor cell differentiation • positive regulation of gene expression • signal transduction • positive regulation of axon regeneration • positive regulation of cell proliferation • astrocyte activation • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1270	12803
Ensembl	ENSG00000242689	ENSMUSG00000079415
UniProt	P26441	P51642
RefSeq (mRNA)	NM_000614	NM_053007 NM_170786
RefSeq (protein)	NP_000605	NP_740756.1 NP_740756
Location (UCSC)	Chr 11: 58.62 – 58.63 Mb	Chr 19: 12.76 – 12.77 Mb
PubMed search

1CNT

1270

12803

ENSG00000242689

ENSMUSG00000079415

P26441

P51642

NM_000614

NM_053007
NM_170786

NP_000605

NP_740756.1
NP_740756

Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene.

The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes. It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also cotranscribed with the upstream ZFP91 gene. Cotranscription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. CNTF has also been shown to be expressed by cells on the bone surface, and to reduce the activity of bone-forming cells (osteoblasts).

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Wikipedia