Chondromodulin I

CNMD
Identifiers
Aliases	CNMD, BRICD3, CHM-I, CHM1, MYETS1, LECT1, leukocyte cell derived chemotaxin 1, chondromodulin
External IDs	MGI: 1341171 HomoloGene: 5095 GeneCards: CNMD
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.3 Start 52,703,264 bp End 52,739,812 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band n/a Start 79,637,690 bp End 79,662,170 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11061	16840
Ensembl	ENSG00000136110	ENSMUSG00000022025
UniProt	O75829	Q9Z1F6
RefSeq (mRNA)	NM_001011705 NM_007015	NM_010701 NM_001310655
RefSeq (protein)	NP_001011705 NP_008946	NP_001297584 NP_034831
Location (UCSC)	Chr 13: 52.7 – 52.74 Mb	Chr 13: 79.64 – 79.66 Mb
PubMed search

11061

16840

ENSG00000136110

ENSMUSG00000022025

O75829

Q9Z1F6

NM_001011705
NM_007015

NM_010701
NM_001310655

NP_001011705
NP_008946

NP_001297584
NP_034831

Chondromodulin-1 is a protein that in humans is encoded by the LECT1 gene.

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage, and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may also be involved in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Wikipedia