Cholesterylester transfer protein

CETP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4F2A, 2OBD, 4EWS
Identifiers
Aliases	CETP, BPIFF, HDLCQ10, cholesteryl ester transfer protein
External IDs	OMIM: 118470 HomoloGene: 47904 GeneCards: CETP
Gene ontology Molecular function • triglyceride binding • phosphatidylcholine binding • lipid transporter activity • phospholipid transporter activity • cholesterol binding • cholesterol transporter activity • lipid binding Cellular component • vesicle • extracellular region • high-density lipoprotein particle • extracellular exosome • extracellular space Biological process • steroid metabolic process • phospholipid homeostasis • lipid transport • lipid metabolic process • phospholipid transport • cholesterol transport • cholesterol metabolic process • regulation of cholesterol efflux • lipid homeostasis • transport • very-low-density lipoprotein particle remodeling • triglyceride transport • cholesterol homeostasis • phosphatidylcholine metabolic process • triglyceride metabolic process • negative regulation of macrophage derived foam cell differentiation • triglyceride homeostasis • reverse cholesterol transport • low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1071	n/a
Ensembl	ENSG00000087237	n/a
UniProt	P11597	n/a
RefSeq (mRNA)	NM_000078 NM_001286085	n/a
RefSeq (protein)	NP_000069 NP_001273014	n/a
Location (UCSC)	Chr 16: 56.96 – 56.98 Mb	n/a
PubMed search		n/a

4F2A, 2OBD, 4EWS

1071

n/a

ENSG00000087237

n/a

P11597

n/a

NM_000078
NM_001286085

n/a

NP_000069
NP_001273014

n/a

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.

The CETP gene is located on the sixteenth chromosome (16q21).

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Wikipedia