Cholesterol side-chain cleavage enzyme

CYP11A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NA1, 3N9Y, 3N9Z, 3NA0
Identifiers
Aliases	CYP11A1, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
External IDs	OMIM: 118485 MGI: 88582 HomoloGene: 37347 GeneCards: CYP11A1
Targeted by Drug
mitotane
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol monooxygenase (side-chain-cleaving) activity Cellular component • membrane • mitochondrial membrane • mitochondrial matrix • mitochondrion Biological process • vitamin D metabolic process • C21-steroid hormone metabolic process • lipid metabolic process • cholesterol metabolic process • C21-steroid hormone biosynthetic process • sterol metabolic process • oxidation-reduction process • steroid biosynthetic process • steroid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1583	13070
Ensembl	ENSG00000140459	ENSMUSG00000032323
UniProt	P05108	Q9QZ82
RefSeq (mRNA)	NM_001099773 NM_000781	NM_019779 NM_001346787
RefSeq (protein)	NP_000772 NP_001093243	NP_062753.3 NP_001333716 NP_062753
Location (UCSC)	Chr 15: 74.34 – 74.37 Mb	Chr 9: 58.01 – 58.03 Mb
PubMed search

cholesterol monooxygenase (side-chain-cleaving)
Identifiers
EC number	1.14.15.6
CAS number	37292-81-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

3NA1, 3N9Y, 3N9Z, 3NA0

1583

13070

ENSG00000140459

ENSMUSG00000032323

P05108

Q9QZ82

NM_001099773
NM_000781

NM_019779
NM_001346787

NP_000772
NP_001093243

NP_062753.3
NP_001333716
NP_062753

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones.

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