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Cholesterol side-chain cleavage enzyme

CYP11A1
3n9y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYP11A1, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
External IDs OMIM: 118485 MGI: 88582 HomoloGene: 37347 GeneCards: CYP11A1
Targeted by Drug
mitotane
RNA expression pattern
PBB GE CYP11A1 204309 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099773
NM_000781

NM_019779
NM_001346787

RefSeq (protein)

NP_000772
NP_001093243

NP_062753.3
NP_001333716
NP_062753

Location (UCSC) Chr 15: 74.34 – 74.37 Mb Chr 9: 58.01 – 58.03 Mb
PubMed search
cholesterol monooxygenase (side-chain-cleaving)
Identifiers
EC number 1.14.15.6
CAS number 37292-81-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

3NA1, 3N9Y, 3N9Z, 3NA0

NM_001099773
NM_000781

NM_019779
NM_001346787

NP_000772
NP_001093243

NP_062753.3
NP_001333716
NP_062753

Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a enzyme that catalyzes conversion of cholesterol to pregnenolone. This is the first reaction in the process of steroidogenesis in all mammalian tissues that specialize in the production of various steroid hormones.


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Wikipedia

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