Cholecystokinin A receptor

CCKAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D6G, 1HZN
Identifiers
Aliases	CCKAR, CCK-A, CCK1-R, CCK1R, CCKRA, cholecystokinin A receptor
External IDs	MGI: 99478 HomoloGene: 37337 GeneCards: CCKAR
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • cholecystokinin receptor activity • peptide binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • axonogenesis • digestion • neuron migration • phospholipase C-activating G-protein coupled receptor signaling pathway • forebrain development • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of hormone secretion • feeding behavior • response to nutrient • cellular response to hormone stimulus • cholecystokinin signaling pathway • response to peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	886	12425
Ensembl	ENSG00000163394	ENSMUSG00000029193
UniProt	P32238	O08786
RefSeq (mRNA)	NM_000730	NM_009827 NM_001347354
RefSeq (protein)	NP_000721	NP_033957.1 NP_001334283 NP_033957
Location (UCSC)	Chr 4: 26.48 – 26.49 Mb	Chr 5: 53.7 – 53.71 Mb
PubMed search

Cholecystokinin A receptor, N-terminal domain
molecular complex of cholecystokinin-8 and n-terminus of the cholecystokinin a receptor by nmr spectroscopy
Identifiers
Symbol	CholecysA-Rec_N
Pfam	PF09193
InterPro	IPR015276
SCOP	1d6g
SUPERFAMILY	1d6g
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1D6G, 1HZN

886

12425

ENSG00000163394

ENSMUSG00000029193

P32238

O08786

NM_000730

NM_009827
NM_001347354

NP_000721

NP_033957.1
NP_001334283
NP_033957

The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK₁, with CCK₁ now being the IUPHAR-recommended name.

This gene encodes a G-protein coupled receptor that binds sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.