Cholecalciferol
 |
|
 |
|
| Clinical data | |
|---|---|
| Pronunciation | /ˌkoʊləkælˈsɪfərɒl/ |
| AHFS/Drugs.com | Professional Drug Facts |
| Pregnancy category |
|
| ATC code | |
| Identifiers | |
|
|
| Synonyms | vitamin D3, activated 7-dehydrocholesterol |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| ECHA InfoCard | 100.000.612 |
| Chemical and physical data | |
| Formula | C27H44O |
| Molar mass | 384.64 g/mol |
| 3D model (Jmol) | |
| Melting point | 83 to 86 °C (181 to 187 °F) |
| Boiling point | 496.4 °C (925.5 °F) |
| Solubility in water | Practically insoluble in water, freely soluble in ethanol, methanol and some other organic solvents. Slightly soluble in vegetable oils. mg/mL (20 °C) |
|
|
|
|
Cholecalciferol, also known as vitamin D3 and colecalciferol, is a type of vitamin D found in food and used as a dietary supplement. As a supplement it is used to treat and prevent vitamin D deficiency including rickets. It is also used for familial hypophosphatemia, hypoparathyroidism that is causing low blood calcium, and Fanconi syndrome. It is taken by mouth.
Excessive doses can result in vomiting, constipation, weakness, and confusion. Other risks include kidney stones. Normal doses are safe in pregnancy. It may not be effective in people with severe kidney disease. After being converted into 1,25-dihydroxyvitamin D, it works by increasing the uptake of calcium by the intestines. Food in which it is found include some fish, cheese, and eggs.
Cholecalciferol was first described in 1936. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Cholecalciferol is available as a generic medication and over the counter. The wholesale cost in the developing world is about 2.14 USD per 30 ml bottle. In the United States treatment costs less than 25 USD per month. Certain foods such as milk have cholecalciferol added to them in some countries.
...
Wikipedia