Chk1

CHEK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IA8, 1NVQ, 1NVR, 1NVS, 1ZLT, 1ZYS, 2AYP, 2BR1, 2BRB, 2BRG, 2BRH, 2BRM, 2BRN, 2BRO, 2C3J, 2C3K, 2C3L, 2CGU, 2CGV, 2CGW, 2CGX, 2E9N, 2E9O, 2E9P, 2E9U, 2E9V, 2GDO, 2GHG, 2HOG, 2HXL, 2HXQ, 2HY0, 2QHM, 2QHN, 2R0U, 2WMQ, 2WMR, 2WMS, 2WMT, 2WMU, 2WMV, 2WMW, 2WMX, 2X8D, 2X8E, 2X8I, 2XEY, 2XEZ, 2XF0, 2YDI, 2YDJ, 2YDK, 2YER, 2YEX, 2YM3, 2YM4, 2YM5, 2YM6, 2YM7, 2YM8, 2YWP, 3F9N, 3JVR, 3JVS, 3NLB, 3OT3, 3OT8, 3PA3, 3PA4, 3PA5, 3TKH, 3TKI, 3U9N, 4FSM, 4FSN, 4FSQ, 4FSR, 4FST, 4FSU, 4FSW, 4FSY, 4FSZ, 4FT0, 4FT3, 4FT5, 4FT7, 4FT9, 4FTA, 4FTC, 4FTI, 4FTJ, 4FTK, 4FTL, 4FTM, 4FTN, 4FTO, 4FTQ, 4FTR, 4FTT, 4FTU, 4GH2, 4HYH, 4HYI, 4JIK, 4QYE, 4QYF, 4QYG, 4QYH, 4RVK, 4RVL, 4RVM, 5DLS, 5F4N
Identifiers
Aliases	CHEK1, CHK1, checkpoint kinase 1
External IDs	MGI: 1202065 HomoloGene: 975 GeneCards: CHEK1
Gene location (Human) Chr. Chromosome 11 (human) Band No data available Start 125,625,136 bp End 125,676,255 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band No data available Start 36,708,482 bp End 36,727,065 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein binding • ATP binding • kinase activity • protein serine/threonine kinase activity • histone kinase activity (H3-T11 specific) • protein domain specific binding Cellular component • cytosol • centrosome • intracellular membrane-bounded organelle • nucleoplasm • microtubule organizing center • condensed nuclear chromosome • chromosome, telomeric region • cytoskeleton • nucleus • extracellular space • chromatin • cytoplasm • protein complex Biological process • regulation of mitotic centrosome separation • regulation of double-strand break repair via homologous recombination • phosphorylation • replicative senescence • G2 DNA damage checkpoint • cellular response to DNA damage stimulus • DNA replication • protein phosphorylation • cellular response to mechanical stimulus • negative regulation of mitotic nuclear division • DNA damage induced protein phosphorylation • cell cycle • peptidyl-threonine phosphorylation • regulation of signal transduction by p53 class mediator • DNA repair • histone H3-T11 phosphorylation • intracellular signal transduction • regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • chromatin-mediated maintenance of transcription • regulation of histone H3-K9 acetylation • DNA damage checkpoint • positive regulation of cell cycle • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1111	12649
Ensembl	ENSG00000149554	ENSMUSG00000032113
UniProt	O14757	O35280
RefSeq (mRNA)	NM_001114121 NM_001114122 NM_001244846 NM_001274 NM_001330427 NM_001330428	NM_007691
RefSeq (protein)	NP_001107593 NP_001107594 NP_001231775 NP_001265 NP_001317356 NP_001317357	NP_031717
Location (UCSC)	Chr 11: 125.63 – 125.68 Mb	Chr 11: 36.71 – 36.73 Mb
PubMed search

1IA8, 1NVQ, 1NVR, 1NVS, 1ZLT, 1ZYS, 2AYP, 2BR1, 2BRB, 2BRG, 2BRH, 2BRM, 2BRN, 2BRO, 2C3J, 2C3K, 2C3L, 2CGU, 2CGV, 2CGW, 2CGX, 2E9N, 2E9O, 2E9P, 2E9U, 2E9V, 2GDO, 2GHG, 2HOG, 2HXL, 2HXQ, 2HY0, 2QHM, 2QHN, 2R0U, 2WMQ, 2WMR, 2WMS, 2WMT, 2WMU, 2WMV, 2WMW, 2WMX, 2X8D, 2X8E, 2X8I, 2XEY, 2XEZ, 2XF0, 2YDI, 2YDJ, 2YDK, 2YER, 2YEX, 2YM3, 2YM4, 2YM5, 2YM6, 2YM7, 2YM8, 2YWP, 3F9N, 3JVR, 3JVS, 3NLB, 3OT3, 3OT8, 3PA3, 3PA4, 3PA5, 3TKH, 3TKI, 3U9N, 4FSM, 4FSN, 4FSQ, 4FSR, 4FST, 4FSU, 4FSW, 4FSY, 4FSZ, 4FT0, 4FT3, 4FT5, 4FT7, 4FT9, 4FTA, 4FTC, 4FTI, 4FTJ, 4FTK, 4FTL, 4FTM, 4FTN, 4FTO, 4FTQ, 4FTR, 4FTT, 4FTU, 4GH2, 4HYH, 4HYI, 4JIK, 4QYE, 4QYF, 4QYG, 4QYH, 4RVK, 4RVL, 4RVM, 5DLS, 5F4N

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