Karl August, Grand Duke of Saxe-Weimar-Eisenach, sometimes Charles Augustus in English (3 September 1757 – 14 June 1828), was a Duke of Saxe-Weimar and of Saxe-Eisenach (in personal union) from 1758, Duke of Saxe-Weimar-Eisenach from its creation (as a political union) in 1809, and grand duke from 1815 until his death. He is noted for the intellectual brilliance of his court.
Born in Weimar, he was the eldest son of Ernst August II, Duke of Saxe-Weimar and Saxe-Eisenach (Ernest Augustus II), and Duchess Anna Amalia of Brunswick-Wolfenbüttel.
His father died when he was only nine months old (28 May 1758), and the boy was brought up under the regency and supervision of his mother. His governor was the Count Johann Eustach von Görtz and in 1771, Christoph Martin Wieland was appointed his tutor. In 1774 the poet Karl Ludwig von Knebel came to Weimar as tutor to his brother, the young Prince Frederick Ferdinand Constantin, and in the same year the two princes set out, with Count Görtz and Knebel, for Paris. At Frankfurt, Knebel introduced Karl August to the young Johann Wolfgang von Goethe.
In Karlsruhe on 3 October 1775, after he returned to Weimar and assumed the government of his duchy, Karl August married Luise Auguste, daughter of Louis IX, Landgrave of Hesse-Darmstadt.