Chambersburg is an unincorporated community in Columbiana County, in the U.S. state of Ohio.
Chambersburg was platted in 1828. A variant name was New Crambersburg(h). A post office called New Chambersburgh was established in 1846, the spelling was changed to New Chambersburg in 1894, and the post office closed in 1904.
Coordinates: 40°47′15″N 81°01′54″W / 40.78750°N 81.03167°W