Centurione II Zaccaria (died 1432), scion of a powerful Genoese merchant family established in the Morea, was installed as Prince of Achaea by Ladislaus of Naples in 1404 and was the last ruler of the Latin Empire not under Byzantine suzerainty.
Centurione was the son of Andronikos Asen Zaccaria and grandson of Centurione I Zaccaria. He succeeded his father in the barony of Arkadia (modern Kyparissia) in 1402. Though young, he was ambitious and he overthrew his aunt, Maria II Zaccaria, in Achaea in 1404; a move which was approved by his overlord, the king of Naples. Immediately, he reinforced his power on a local basis by marrying Creusa, the daughter of , lord of Zante and niece of whose dominions covered Cephalonia and Lefkada and extended to Epirus and the western Peloponnese. Centurione then made his brother Stephen the Latin Archbishop of Patras.
However, Centurione was quickly at war with his alienated relatives. His wife's cousin , duke of Leucas, had Ladislaus absolve him from his feudal obligations to Achaea (1406) and then, allied with Theodore I Palaiologos, Despot of Morea, made war on the principality, conquering Glarentza (1408), long the principality's chief seaport. His brother Stephen, however, abandoned the diocese of Patras to the Venetians on loan for five years. Centurione himself was forced to ally with the Venetians and Justinian, Lord of Chios, and to hire Albanian mercenaries to retake the port on 12 July 1414. In return for military protection, he granted the ports of Glarentza and Navarino to the Giustiniani family of Genoa.