Central Denmark Region (Danish: Region Midtjylland) is an administrative region of Denmark established on 1 January 2007 as part of the 2007 Danish Municipal Reform, which replaced the traditional counties ("amter") with five larger regions. At the same time, smaller municipalities were merged into larger units, cutting the number of municipalities from 271 before 1 January 2006, when Ærø Municipality was created, to 98. The reform was implemented in Denmark on 1 January 2007.

Central Denmark Region is located on the north-central portion of the Jutland peninsula and consists of the former counties of Ringkjøbing and Århus (save the western half of Mariager municipality which joined Region Nordjylland), most of the former county of Viborg, and the northern half of Vejle County. The areas in question from the two latter counties were the former municipalities of Bjerringbro, Fjends, Hvorslev, Karup, Kjellerup, Møldrup, Sallingsund, Skive, Spøttrup, Sundsøre, Tjele, and Viborg from Viborg County and Brædstrup, Gedved, Hedensted, Horsens, Juelsminde, Nørre-Snede and Tørring-Uldum from Vejle County.

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