Central Denmark Region (Danish: Region Midtjylland) is an administrative region of Denmark established on 1 January 2007 as part of the 2007 Danish Municipal Reform, which abolished the traditional counties ("amter") and set up five larger regions. At the same time, smaller municipalities were merged into larger units, cutting the number of municipalities from 271 before 1 January 2006, when Ærø Municipality was created, to 98. The Central Denmark Region has 19 municipalities. The reform was implemented in Denmark on 1 January 2007.

The Danish name of the region means "region of central Jutland", as opposed to Northern Jutland and Southern Jutland. As such, the official English translation of this place name is not , but rather refers to the geography of Denmark, as a whole.

Central Denmark Region is located on the north-central portion of the Jutland peninsula and consists of the former counties of Ringkjøbing and Århus (save the western half of Mariager municipality which joined Region Nordjylland), most of the former county of Viborg, and the northern half of Vejle County. The areas in question from the two latter counties were the former municipalities of Bjerringbro, Fjends, Hvorslev, Karup, Kjellerup, Møldrup, Sallingsund, Skive, Spøttrup, Sundsøre, Tjele, and Viborg from Viborg County and Brædstrup, Gedved, Hedensted, Horsens, Juelsminde, Nørre-Snede and Tørring-Uldum from Vejle County.

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