Cdc42

CDC42
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR, 4JS0, 4YC7, 5FI1
Identifiers
Aliases	CDC42, CDC42Hs, G25K, TKS, cell division cycle 42
External IDs	OMIM: 116952 HomoloGene: 123986 GeneCards: CDC42
Gene ontology Molecular function • Rho GDP-dissociation inhibitor binding • ubiquitin protein ligase activity • apolipoprotein A-I receptor binding • GTP-dependent protein binding • GTPase activity • mitogen-activated protein kinase kinase kinase binding • protein binding • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • identical protein binding Cellular component • cytoplasm • cytosol • membrane • cell-cell junction • focal adhesion • microtubule organizing center • spindle midzone • neuron projection • storage vacuole • cytoskeleton • cell projection • myelin sheath • extracellular exosome • filopodium • plasma membrane • spindle • apical part of cell • secretory granule • neuronal cell body • cytoplasmic ribonucleoprotein granule • mitotic spindle • leading edge membrane • cell periphery • endoplasmic reticulum membrane • Golgi membrane • midbody Biological process • cardiac conduction system development • positive regulation of protein phosphorylation • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of muscle cell differentiation • nuclear migration • keratinization • positive regulation of JNK cascade • establishment of Golgi localization • actin filament bundle assembly • positive regulation of neuron apoptotic process • vascular endothelial growth factor receptor signaling pathway • hair follicle morphogenesis • heart contraction • regulation of protein stability • neuron fate determination • substantia nigra development • Fc-gamma receptor signaling pathway involved in phagocytosis • actin filament organization • negative regulation of protein complex assembly • epithelial-mesenchymal cell signaling • actin filament branching • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • establishment or maintenance of cell polarity • positive regulation of cell growth • regulation of protein metabolic process • establishment or maintenance of apical/basal cell polarity • regulation of protein kinase activity • regulation of attachment of spindle microtubules to kinetochore • regulation of small GTPase mediated signal transduction • positive regulation of hair follicle cell proliferation • positive regulation of MAPK cascade • regulation of mitotic nuclear division • hair follicle placode formation • positive regulation of intracellular protein transport • single organismal cell-cell adhesion • cell differentiation • positive regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of protein heterodimerization activity • Golgi organization • positive regulation of synapse structural plasticity • multicellular organism growth • epidermis morphogenesis • nucleus localization • epithelial cell-cell adhesion • sprouting angiogenesis • nervous system development • macrophage differentiation • dendritic cell migration • positive regulation of cytokinesis • positive regulation of DNA replication • Wnt signaling pathway, planar cell polarity pathway • keratinocyte development • regulation of protein catabolic process • canonical Wnt signaling pathway • adherens junction organization • organelle transport along microtubule • actin cytoskeleton organization • regulation of filopodium assembly • endocytosis • ephrin receptor signaling pathway • filopodium assembly • T cell costimulation • blood coagulation • positive regulation of phosphatidylinositol 3-kinase activity • cellular protein localization • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of gene expression • positive regulation of pseudopodium assembly • submandibular salivary gland formation • viral RNA genome replication • small GTPase mediated signal transduction • protein ubiquitination • positive regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	998	n/a
Ensembl	ENSG00000070831	n/a
UniProt	P60953	n/a
RefSeq (mRNA)	NM_044472 NM_001039802 NM_001791	n/a
RefSeq (protein)	NP_001034891 NP_001782 NP_426359	n/a
Location (UCSC)	Chr 1: 22.05 – 22.09 Mb	n/a
PubMed search		n/a

Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.

4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR, 4JS0, 4YC7, 5FI1

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