Cdc20

CDC20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GGA, 4GGC, 4GGD, 4N14, 5G04
Identifiers
Aliases	CDC20, CDC20A, bA276H19.3, p55CDC, cell division cycle 20
External IDs	MGI: 1859866 HomoloGene: 37459 GeneCards: CDC20
Gene ontology Molecular function • histone deacetylase binding • protein C-terminus binding • protein binding • anaphase-promoting complex binding • ubiquitin-protein transferase activator activity • enzyme binding Cellular component • cytosol • centrosome • spindle pole • spindle • microtubule organizing center • protein complex • perinuclear region of cytoplasm • anaphase-promoting complex • cytoskeleton • nucleoplasm • cytoplasm Biological process • cell differentiation • regulation of meiotic nuclear division • regulation of dendrite development • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • nervous system development • positive regulation of synaptic plasticity • cell division • positive regulation of synapse maturation • protein ubiquitination • positive regulation of cell proliferation • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • proteasome-mediated ubiquitin-dependent protein catabolic process • anaphase-promoting complex-dependent catabolic process • positive regulation of ubiquitin protein ligase activity • sister chromatid cohesion • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • mitotic sister chromatid cohesion • protein deubiquitination • mitotic spindle assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	991	107995
Ensembl	ENSG00000117399	ENSMUSG00000006398
UniProt	Q12834	Q9JJ66
RefSeq (mRNA)	NM_001255	NM_023223
RefSeq (protein)	NP_001246	NP_075712.2 NP_075712
Location (UCSC)	Chr 1: 43.36 – 43.36 Mb	Chr 4: 118.43 – 118.44 Mb
PubMed search

4GGA, 4GGC, 4GGD, 4N14, 5G04

991

107995

ENSG00000117399

ENSMUSG00000006398

Q12834

Q9JJ66

NM_001255

NM_023223

NP_001246

NP_075712.2
NP_075712

The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

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Wikipedia