Cattaraugus Reservation is an Indian reservation in Cattaraugus County, New York, United States. The population was 314 at the 2010 census. The majority of the residents are of the Seneca Nation.
The majority of the reservation is in Erie County and a small part is in Chautauqua County.
According to the United States Census Bureau, the Indian reservation has a total area of 6.0 mi² (15.5 km²). 5.8 mi² (14.9 km²) of it is land and 0.2 mi² (0.6 km²) of it (3.68%) is water.
Cattaraugus Creek runs through the middle of the reservation, and Lake Erie forms part of the western boundary.
As of the census of 2000, there were 388 people, 127 households, and 94 families residing in the Indian reservation. The population density was 67.4/mi² (26.0/km²). There were 136 housing units at an average density of 23.6/mi² (9.1/km²). The racial makeup of the Indian reservation was 4.38% White and 95.62% Native American. Hispanic or Latino of any race were 4.12% of the population.
There were 127 households out of which 49.6% had children under the age of 18 living with them, 32.3% were married couples living together, 35.4% had a female householder with no husband present, and 25.2% were non-families. 20.5% of all households were made up of individuals and 1.6% had someone living alone who was 65 years of age or older. The average household size was 3.06 and the average family size was 3.52.