Cation-dependent mannose-6-phosphate receptor

M6PR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JUQ
Identifiers
Aliases	M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR, CD-mannose-6-phosphate receptor, cation dependent
External IDs	MGI: 96904 HomoloGene: 31086 GeneCards: M6PR
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 8,940,363 bp End 8,949,955 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 F1|6 57.52 cM Start 122,308,720 bp End 122,317,680 bp
Gene ontology Molecular function • mannose transmembrane transporter activity • mannose binding • transmembrane signaling receptor activity • protein binding • retromer complex binding Cellular component • perinuclear region of cytoplasm • integral component of membrane • lysosomal membrane • endosome • late endosome • lysosome • integral component of plasma membrane • lytic vacuole • membrane • trans-Golgi network membrane • transport vesicle • plasma membrane • clathrin-coated vesicle membrane • retromer complex • trans-Golgi network Biological process • mannose transport • receptor-mediated endocytosis • endosome to lysosome transport • signal transduction • secretion of lysosomal enzymes • membrane organization • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4074	17113
Ensembl	ENSG00000003056	ENSMUSG00000007458
UniProt	P20645	P24668
RefSeq (mRNA)	NM_001207024 NM_002355	NM_010749
RefSeq (protein)	NP_001193953 NP_002346	NP_034879
Location (UCSC)	Chr 12: 8.94 – 8.95 Mb	Chr 12: 122.31 – 122.32 Mb
PubMed search

1JUQ

4074

17113

ENSG00000003056

ENSMUSG00000007458

P20645

P24668

NM_001207024
NM_002355

NM_010749

NP_001193953
NP_002346

NP_034879

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.

The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes.

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