Cathepsin K

CTSK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8
Identifiers
Aliases	CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
External IDs	OMIM: 601105 MGI: 107823 HomoloGene: 68053 GeneCards: CTSK
Targeted by Drug
odanacatib
Gene ontology Molecular function • fibronectin binding • cysteine-type peptidase activity • collagen binding • peptidase activity • protein binding • cysteine-type endopeptidase activity • hydrolase activity • proteoglycan binding • serine-type endopeptidase activity Cellular component • cytoplasm • extracellular region • endolysosome lumen • lysosome • extracellular space • nucleoplasm • intracellular membrane-bounded organelle Biological process • intramembranous ossification • positive regulation of protein targeting to mitochondrion • extracellular matrix disassembly • bone resorption • proteolysis • toll-like receptor signaling pathway • regulation of mitophagy • collagen catabolic process • proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1513	13038
Ensembl	ENSG00000143387	ENSMUSG00000028111
UniProt	P43235	P55097
RefSeq (mRNA)	NM_000396	NM_007802
RefSeq (protein)	NP_000387	NP_031828.2 NP_031828
Location (UCSC)	Chr 1: 150.8 – 150.81 Mb	Chr 3: 95.5 – 95.51 Mb
PubMed search

1MEM, 3KWB, 3KX1, 4X6J, 1AYW, 3KW9, 1YT7, 1AU2, 4X6H, 1Q6K, 1YK7, 1ATK, 3C9E, 1AYV, 1BGO, 4N8W, 7PCK, 4DMX, 4X6I, 1NL6, 1TU6, 3O0U, 1AU4, 3OVZ, 3KWZ, 2ATO, 3O1G, 1AU0, 1BY8, 1SNK, 2AUZ, 4DMY, 4N79, 1AYU, 1U9X, 1YK8, 1AU3, 1U9V, 2BDL, 1VSN, 1U9W, 2AUX, 2R6N, 3H7D, 1NLJ, 5J94, 4YVA, 4YV8

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