Cathepsin H

CTSH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BZN
Identifiers
Aliases	CTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
External IDs	MGI: 107285 HomoloGene: 36159 GeneCards: CTSH
Gene ontology Molecular function • peptidase activator activity involved in apoptotic process • cysteine-type peptidase activity • HLA-A specific activating MHC class I receptor activity • endopeptidase activity • protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • cysteine-type endopeptidase activity • aminopeptidase activity • serine-type endopeptidase activity • hydrolase activity • thyroid hormone binding • peptidase activity Cellular component • cytosol • alveolar lamellar body • lysosome • extracellular exosome • multivesicular body lumen • P-body • extracellular region • extracellular space • secretory granule lumen • intracellular membrane-bounded organelle • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • surfactant homeostasis • cellular protein metabolic process • antigen processing and presentation • adaptive immune response • bradykinin catabolic process • response to retinoic acid • membrane protein proteolysis • positive regulation of cell migration • ERK1 and ERK2 cascade • zymogen activation • neuropeptide catabolic process • positive regulation of epithelial cell migration • positive regulation of apoptotic signaling pathway • negative regulation of apoptotic process • proteolysis • positive regulation of angiogenesis • positive regulation of peptidase activity • positive regulation of gene expression • protein destabilization • cellular response to thyroid hormone stimulus • positive regulation of cell proliferation • immune response-regulating signaling pathway • proteolysis involved in cellular protein catabolic process • metanephros development • dichotomous subdivision of terminal units involved in lung branching • T cell mediated cytotoxicity • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1512	13036
Ensembl	ENSG00000103811	ENSMUSG00000032359
UniProt	P09668	P49935
RefSeq (mRNA)	NM_004390 NM_148979 NM_001319137	NM_007801 NM_001312649
RefSeq (protein)	NP_001306066 NP_004381	NP_001299578.1 NP_031827.2 NP_001299578 NP_031827
Location (UCSC)	Chr 15: 78.92 – 78.95 Mb	Chr 9: 90.05 – 90.08 Mb
PubMed search

1BZN

1512

13036

ENSG00000103811

ENSMUSG00000032359

P09668

P49935

NM_004390
NM_148979
NM_001319137

NM_007801
NM_001312649

NP_001306066
NP_004381

NP_001299578.1
NP_031827.2
NP_001299578
NP_031827

Cathepsin H is a protein that in humans is encoded by the CTSH gene.

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.

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