Cathepsin G

CTSG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AU8, 1CGH, 1KYN, 1T32
Identifiers
Aliases	CTSG, CATG, CG, cathepsin G
External IDs	OMIM: 116830 MGI: 88563 HomoloGene: 105646 GeneCards: CTSG
Gene ontology Molecular function • heparin binding • peptidase activity • protein binding • hydrolase activity • serine-type endopeptidase activity • serine-type peptidase activity Cellular component • extracellular matrix • plasma membrane • secretory granule • extracellular region • cell surface • extracellular exosome • nucleus • extracellular space • azurophil granule lumen • cytoplasmic stress granule Biological process • cellular protein metabolic process • neutrophil mediated killing of gram-positive bacterium • negative regulation of growth of symbiont in host • protein processing • extracellular matrix disassembly • defense response to fungus • proteolysis • angiotensin maturation • protein phosphorylation • response to lipopolysaccharide • positive regulation of immune response • defense response to bacterium • immune response • defense response to Gram-positive bacterium • antimicrobial humoral response • neutrophil degranulation • antibacterial humoral response • defense response to Gram-negative bacterium • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1511	13035
Ensembl	ENSG00000100448	ENSMUSG00000040314
UniProt	P08311	P28293
RefSeq (mRNA)	NM_001911	NM_007800
RefSeq (protein)	NP_001902	NP_031826.1 NP_031826
Location (UCSC)	Chr 14: 24.57 – 24.58 Mb	Chr 14: 56.1 – 56.1 Mb
PubMed search

1AU8, 1CGH, 1KYN, 1T32

1511

13035

ENSG00000100448

ENSMUSG00000040314

P08311

P28293

NM_001911

NM_007800

NP_001902

NP_031826.1
NP_031826

Cathepsin G is in humans encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family, Cathepsin G plays an important role in eliminating intracellular pathogens and breaking down tissues at inflammatory sites, as well as in anti-inflammatory response.

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Wikipedia