Cathelicidin

CAMP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EYC, 2FBS, 2FBU, 2FCG, 2K6O, 2LMF
Identifiers
Aliases	CAMP, CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26, LL37, cathelicidin antimicrobial peptide
External IDs	OMIM: 600474 MGI: 108443 HomoloGene: 110678 GeneCards: CAMP
Gene ontology Molecular function • protein binding Cellular component • extracellular region • specific granule • intracellular • extracellular exosome • extracellular space • specific granule lumen • tertiary granule lumen Biological process • positive regulation of interleukin-8 secretion • antibacterial humoral response • defense response • response to yeast • negative regulation of growth of symbiont on or near host surface • innate immune response in mucosa • innate immune response • killing by host of symbiont cells • chronic inflammatory response • defense response to Gram-negative bacterium • antifungal humoral response • defense response to Gram-positive bacterium • defense response to bacterium • antimicrobial humoral response • neutrophil degranulation • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	820	12796
Ensembl	ENSG00000164047	ENSMUSG00000038357
UniProt	P49913	P51437
RefSeq (mRNA)	NM_004345	NM_009921
RefSeq (protein)	NP_004336	NP_034051.2 NP_034051
Location (UCSC)	Chr 3: 48.22 – 48.23 Mb	Chr 9: 109.85 – 109.85 Mb
PubMed search

Cathelicidin
Crystal Structure Analysis of the Cathelicidin Motif of Protegrins
Identifiers
Symbol	Cathelicidin
Pfam	PF00666
Pfam clan	CL0121
InterPro	IPR001894
PROSITE	PDOC00729
SCOP	1lyp
SUPERFAMILY	1lyp
OPM superfamily	236
OPM protein	2k6o
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

4EYC, 2FBS, 2FBU, 2FCG, 2K6O, 2LMF

820

12796

ENSG00000164047

ENSMUSG00000038357

P49913

P51437

NM_004345

NM_009921

NP_004336

NP_034051.2
NP_034051

Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes (PMNs), and keratinocytes. Cathelicidins serve a critical role in mammalian innate immune defense against invasive bacterial infection. The cathelicidin family of peptides are classified as antimicrobial peptides (AMPs). The AMP family also includes the defensins. Whilst the defensins share common structural features, cathelicidin-related peptides are highly heterogeneous.